The action takes place in Seville of sixteenth century during the Bubonic plague outbreak. Mateo, a former soldier, comes back to Seville to find the son of his dead friend. Earlier Mateo was forced to run away from the city due the inquisition had sentenced him to death for prohibited books printing. When Mateo is back to Seville he is arrested by inquisition. But he is promised to be pardoned if he will reveal the series of devilish crimes that committed in the city.